PHYTOCHEMICAL ANALYSIS AND THE ANTIINFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII

PHYTOCHEMICAL ANALYSIS AND THE ANTIINFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII

ABSTRACT

Inflammation is a complex biological reaction of vascular tissue to adverse stimuli such as pathogens, damaged cells, or irritants (Ryan & Majno, 1983). The urgency created by the increased rate of stroke and atherosclerosis associated with the prolonged use of cyclooxygenase-1 and cyclooxygenase-2 inhibitors has accelerated anti-inflammatory drug research over the last decade, while synthetic pharmaceutical agents have continued to dominate research (Ryan & Majno, 1983). Natural products have received an increasing amount of attention. These are frequently less expensive and more widely available, and they are sometimes thought to be more effective than traditional anti-inflammatory medications. Anti-inflammation was carried out on 12 rats, which were separated into three groups of four each. Groups 1 and 2 functioned as negative and positive controls, respectively. Group 3 got 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii, which demonstrated significant anti-inflammatory efficacy as compared to the standard difference utilised.