30 Medical Laboratory Science Final Year Project Topics

Latest Final Year Project Topics for Medical Laboratory Science Students in 2026

Estimated Reading Time: 4-5 minutes to review all topics and guidance | 15-20 minutes for comprehensive selection process

Introduction

Selecting the right final year project topic is one of the most critical decisions you’ll make as a medical laboratory science student. The pressure to choose something original, research-worthy, and achievable can feel overwhelming, especially when you’re balancing coursework, clinical rotations, and other academic responsibilities. Your project isn’t just another assignment—it’s an opportunity to demonstrate your expertise, contribute to advancing diagnostic practices, and showcase your ability to conduct rigorous scientific research that could influence laboratory standards and patient care outcomes.

For medical laboratory science final year project topics, relevance and current applicability are essential. The field is evolving rapidly with emerging diagnostic techniques, increased focus on laboratory quality control, the rise of molecular diagnostics, and a growing emphasis on biomarkers in clinical pathology. Selecting a topic aligned with these contemporary trends ensures your research remains valuable to the healthcare industry and positions you as a forward-thinking laboratory professional.

This comprehensive guide provides 30 well-researched, current final year project topics designed specifically for medical laboratory science students in 2026. These topics span diagnostic techniques, laboratory quality control systems, biomarkers, molecular diagnostics, clinical pathology applications, and emerging laboratory technologies. Each topic is structured to be achievable within your project timeline while providing sufficient depth for rigorous academic investigation. Whether you’re interested in immunology, hematology, clinical chemistry, microbiology, or parasitology, you’ll find relevant options that align with your career aspirations and academic strengths.

How to Choose the Right Final Year Project Topic

Selecting your medical laboratory science final year project topic requires careful consideration of several factors to ensure success and meaningful contribution to your field:

• Relevance and Currency: Choose topics addressing current challenges or emerging trends in laboratory diagnostics, ensuring your research contributes meaningful insights to your field. Contemporary topics attract more attention from supervisors and demonstrate awareness of modern laboratory practice.
• Feasibility and Resources: Consider your access to laboratory facilities, equipment, and study populations; ensure your chosen topic is achievable within your institution’s capabilities and project timeline. Some topics may require specialized equipment or collaborative partnerships with clinical facilities.
• Personal Interest: Select a topic you’re genuinely passionate about investigating, as this enthusiasm will sustain you through the research and writing process. Your genuine interest will reflect in the quality of your work and findings.
• Scope and Specificity: Ensure your topic is neither too broad nor too narrow; it should allow comprehensive investigation without becoming unmanageable. A well-defined scope prevents scope creep and ensures completion within your timeframe.
• Practical Applications: Prioritize topics with clear clinical or laboratory applications, demonstrating how your research will benefit diagnostic practices or patient care. Topics with practical relevance are more likely to be implemented in healthcare settings.

Additionally, consult with your academic supervisor early in the selection process. They can provide valuable guidance based on available resources, departmental research priorities, and current gaps in laboratory practice knowledge. Consider whether you prefer bench-based experimental research, literature reviews, quality improvement studies, or diagnostic evaluation studies—your preference should guide topic selection.

Diagnostic Techniques and Laboratory Procedures

This section encompasses topics focused on laboratory methodologies, diagnostic procedures, and technical innovations in specimen analysis and result generation. These topics offer opportunities to evaluate current diagnostic practices, compare methodological approaches, and optimize laboratory procedures for improved accuracy and efficiency.

Topic 1: Comparative Evaluation of Automated and Manual Blood Cell Counting Methods in Nigerian Medical Laboratories

This research compares accuracy, efficiency, and cost-effectiveness of automated versus manual cell counting techniques, evaluating consistency across different laboratory settings. The study would investigate how automation impacts diagnostic accuracy, turnaround time, and operational costs in various healthcare facilities. You would assess hematology analyzer performance across different patient populations, examine result reproducibility, and determine optimal methodologies for different laboratory environments. This topic addresses practical laboratory challenges and provides evidence-based recommendations for equipment investment decisions.

Topic 2: The Impact of Sample Collection and Handling Protocols on Blood Culture Contamination Rates in Healthcare Facilities

This study examines how proper phlebotomy techniques and sample handling procedures reduce contamination, investigating training effectiveness and protocol compliance. Blood culture contamination represents a significant challenge in clinical microbiology, affecting patient management and healthcare costs. Your research would evaluate current collection practices, identify contamination sources, assess staff training effectiveness, and propose standardized protocols. The study could include contamination rate monitoring before and after protocol implementation, demonstrating the practical impact of procedural compliance.

Topic 3: Assessment of Rapid Diagnostic Test Accuracy for Malaria Detection in Endemic Nigerian Regions

This research evaluates the sensitivity and specificity of rapid malaria diagnostic tests compared to microscopy standards, assessing reliability across different parasite densities. Malaria remains a significant public health challenge, and rapid diagnostic tests enable quick treatment initiation in resource-limited settings. Your study would compare different rapid test brands, evaluate performance across various parasite densities, assess test stability and storage conditions, and determine cost-effectiveness. This research directly supports improved malaria diagnosis and treatment outcomes.

Topic 4: Optimization of Enzyme-Linked Immunosorbent Assay Procedures for Improved HIV Antibody Detection in Resource-Limited Settings

This study focuses on enhancing ELISA protocols to increase sensitivity without requiring sophisticated equipment, suitable for laboratories with limited resources. HIV screening remains crucial in resource-limited healthcare settings where advanced molecular diagnostics may be unavailable. Your research would evaluate protocol modifications, assess reagent availability and stability, investigate temperature and environmental factor impacts, and develop simplified procedures maintaining diagnostic accuracy. This topic addresses real-world laboratory challenges in developing healthcare systems.

Topic 5: Evaluation of Point-of-Care Testing Devices for Glucose Monitoring Among Diabetic Patients in Primary Healthcare Centers

This research assesses accuracy, reliability, and cost-effectiveness of portable glucose meters, examining patient outcomes and healthcare provider satisfaction. Point-of-care testing enables immediate glucose assessment and treatment decisions in primary care settings. Your study would evaluate device accuracy compared to laboratory standards, assess patient usability and satisfaction, examine cost-effectiveness, and determine impact on diabetes management outcomes. The research provides evidence supporting point-of-care testing implementation in primary healthcare facilities.

Laboratory Quality Control and Standardization

Quality control and standardization topics focus on ensuring laboratory result reliability, maintaining consistent performance standards, and achieving international accreditation benchmarks. These research areas address systematic approaches to quality assurance and continuous laboratory improvement—critical for patient safety and healthcare provider confidence in laboratory results.

Topic 6: Implementation of Internal Quality Control Standards in Nigerian Medical Laboratories: Challenges and Solutions

This study investigates barriers to standardized quality control protocols, proposing practical solutions for achieving laboratory accreditation and maintaining consistency. Many Nigerian laboratories struggle with implementing rigorous quality control programs due to resource limitations, staff training gaps, and equipment constraints. Your research would identify specific implementation barriers, document current quality control practices, evaluate effectiveness of different solution strategies, and propose context-appropriate recommendations. The study contributes to advancing laboratory standardization across healthcare facilities.

Topic 7: Assessment of Laboratory Information Management System Effectiveness in Reducing Turnaround Time for Test Results

This research evaluates how integrated LIMS improves result reporting speed, examines error reduction, and measures impact on clinical decision-making processes. Laboratory information management systems represent significant investments requiring careful evaluation of return on investment and operational benefits. Your study would measure pre- and post-LIMS implementation turnaround times, assess error reduction, evaluate user satisfaction among laboratory and clinical staff, and calculate cost-effectiveness. The research provides evidence supporting LIMS implementation decisions in healthcare facilities.

Topic 8: Compliance with International Organization for Standardization Standards Among Accredited and Non-Accredited Laboratories

This study compares ISO 15189 compliance levels, identifying gaps and recommending strategies for achieving and maintaining international standards. ISO 15189 accreditation ensures laboratory competence and result reliability. Your research would audit laboratory practices against ISO standards, identify compliance gaps in both accredited and non-accredited facilities, investigate barriers to compliance, and assess resource requirements for achieving accreditation. This research supports laboratory standardization and international recognition efforts.

Topic 9: The Role of Proficiency Testing Programs in Enhancing Diagnostic Accuracy Among Laboratory Professionals

This research examines how participation in external quality assurance programs improves laboratory performance, professional competence, and patient safety outcomes. Proficiency testing programs provide standardized samples enabling comparison of laboratory performance with peers and reference standards. Your study would evaluate proficiency testing participation rates, analyze performance trends, assess impact on laboratory accuracy metrics, and examine correlation with accreditation outcomes. The research demonstrates proficiency testing value in quality improvement.

Topic 10: Development and Validation of Standard Operating Procedures for Blood Transfusion Compatibility Testing

This study creates comprehensive SOP documentation for blood grouping and crossmatching, ensuring consistency and reducing transfusion-related adverse events. Standardized procedures prevent transfusion errors and complications. Your research would review current transfusion medicine practices, develop comprehensive SOPs addressing specimen identification, testing methodology, result interpretation, and documentation, implement procedures in healthcare facilities, and evaluate effectiveness in reducing adverse events. This practical research directly impacts patient safety.

Biomarkers and Clinical Applications

Biomarker research focuses on identifying and validating laboratory markers that predict disease presence, severity, progression, or treatment response. These topics align with personalized medicine approaches and contemporary diagnostic trends emphasizing precision medicine and risk stratification.

Topic 11: Evaluation of Cardiac Biomarkers in Early Detection of Acute Myocardial Infarction Among Nigerian Patients

This research investigates troponin and myoglobin utility in acute heart attack diagnosis, comparing timing and diagnostic accuracy across patient populations. Cardiac biomarkers enable early myocardial infarction detection before electrocardiographic changes. Your study would evaluate biomarker kinetics in Nigerian patient populations, assess diagnostic accuracy across demographic groups, examine relationship between biomarker levels and infarction severity, and determine optimal testing intervals. The research contributes to improved acute coronary syndrome diagnosis in Nigerian healthcare settings.

Topic 12: Assessment of Inflammatory Biomarkers in Predicting Disease Severity Among COVID-19 Patients in West African Healthcare Settings

This study examines C-reactive protein, procalcitonin, and interleukin levels as predictors of severe illness, informing clinical management decisions. Inflammatory biomarkers help identify COVID-19 patients at high risk for severe disease requiring intensive intervention. Your research would evaluate biomarker performance in West African populations, assess predictive value in disease severity stratification, examine correlation with clinical outcomes, and recommend optimal testing protocols. This research supports evidence-based COVID-19 patient management.

Topic 13: Diagnostic Value of Tumor Markers in Early Cancer Detection and Treatment Monitoring Programs

This research evaluates PSA, CEA, and CA-125 effectiveness in cancer screening and surveillance, assessing clinical sensitivity and specificity outcomes. Tumor markers support cancer detection and treatment response monitoring. Your study would assess marker performance in your patient population, evaluate screening effectiveness in asymptomatic individuals, examine utility in treatment response evaluation, and investigate relationship between marker levels and cancer outcomes. The research clarifies tumor marker clinical applications and limitations.

Topic 14: The Role of Homocysteine and Other Metabolic Markers in Cardiovascular Risk Assessment Among Nigerian Population

This study investigates metabolic biomarkers predictive of cardiovascular disease, contributing to risk stratification and preventive healthcare strategies. Cardiovascular disease represents a leading cause of mortality requiring effective risk prediction tools. Your research would measure biomarker levels in your patient population, assess correlation with cardiovascular disease risk factors, evaluate combined biomarker predictive value, and determine clinical utility in risk stratification. The research supports personalized cardiovascular disease prevention approaches.

Topic 15: Evaluation of Renal Function Biomarkers in Early Detection of Chronic Kidney Disease Progression

This research examines creatinine, cystatin C, and proteinuria as early indicators, assessing their combined value in disease monitoring and management planning. Early chronic kidney disease detection enables intervention preventing disease progression. Your study would evaluate biomarker performance in disease detection and staging, assess progression prediction accuracy, examine treatment response relationships, and recommend optimal monitoring protocols. The research improves chronic kidney disease diagnosis and management.

Molecular Diagnostics and Genetic Testing

Molecular diagnostics topics focus on DNA/RNA-based testing methodologies, genetic mutation detection, and emerging molecular technologies. These areas represent rapidly advancing diagnostic frontiers with significant clinical applications in infectious disease, genetic disorder, and cancer diagnostics.

Topic 16: Implementation of Polymerase Chain Reaction Technology for Diagnosing Infectious Diseases in Resource-Limited Laboratory Environments

This study develops simplified PCR protocols requiring minimal equipment, enabling molecular diagnosis without advanced infrastructure investments. PCR technology dramatically improves diagnostic accuracy but typically requires expensive equipment and expertise. Your research would develop simplified procedures, evaluate performance with basic equipment, assess cost-effectiveness, and establish implementation feasibility in resource-limited settings. The research extends molecular diagnostic capabilities to underserved healthcare facilities.

Topic 17: Comparative Analysis of DNA Sequencing Methods for Identifying Drug-Resistant Tuberculosis Mutations in Clinical Isolates

This research evaluates different sequencing approaches for detecting resistance genes, improving treatment selection and reducing therapy failure rates. Drug-resistant tuberculosis requires accurate resistance detection for appropriate treatment selection. Your study would compare sequencing methodologies for resistance gene detection, assess accuracy and cost-effectiveness, evaluate turnaround time differences, and determine optimal approaches for different laboratory settings. The research improves tuberculosis treatment outcomes through accurate resistance detection.

Topic 18: Development of Real-Time PCR Assays for Rapid Detection of Hepatitis C Virus in Blood Donor Screening Programs

This study optimizes RT-PCR sensitivity for detecting low viral loads, improving blood bank safety and reducing window period transmission risk. Hepatitis C virus screening protects blood recipients from transfusion-transmitted infection. Your research would develop optimized RT-PCR assays, evaluate sensitivity in detecting low viral loads, assess window period reduction, and examine implementation feasibility in blood banking laboratories. The research enhances transfusion safety.

Topic 19: Assessment of Whole Blood and Dried Blood Spot Collection Methods for Newborn Screening in Nigerian Healthcare Facilities

This research compares collection techniques, transport stability, and analytical accuracy, evaluating feasibility for expanded newborn screening programs. Dried blood spot collection enables newborn screening in resource-limited settings without specialized blood collection infrastructure. Your study would compare collection methods, assess sample stability during transport, evaluate analytical accuracy, and determine implementation feasibility for newborn screening programs. The research supports expanded newborn screening in healthcare settings.

Topic 20: Evaluation of Next-Generation Sequencing Applications in Identifying Genetic Predisposition to Hematologic Malignancies

This study explores NGS utility in detecting inherited mutations, supporting early identification and family counseling in cancer-prone families. Next-generation sequencing enables comprehensive genetic screening identifying hereditary cancer predisposition. Your research would evaluate NGS performance in detecting predisposition mutations, assess clinical utility in family screening, examine cost-effectiveness, and determine optimal testing protocols. The research supports precision oncology and cancer prevention approaches.

Clinical Pathology and Hematology

Clinical pathology and hematology topics address blood and bone marrow analysis, coagulation testing, hemoglobinopathy screening, and hematologic malignancy diagnosis. These areas encompass fundamental diagnostic disciplines with direct clinical applicability in patient management.

Topic 21: Assessment of Coagulation Profile Testing Accuracy in Predicting Hemorrhagic and Thrombotic Complications in Surgical Patients

This research evaluates PT, aPTT, and fibrinogen utility in perioperative risk stratification, improving preoperative evaluation protocols. Coagulation testing guides perioperative management and identifies patients at risk for bleeding or thrombotic complications. Your study would evaluate coagulation test accuracy in complication prediction, assess relationship between test abnormalities and postoperative outcomes, examine testing utility in risk stratification, and recommend preoperative testing protocols. The research improves surgical patient safety.

Topic 22: Impact of Anticoagulant Choice on Blood Specimen Quality and Laboratory Test Results Validity

This study examines EDTA, citrate, and lithium heparin effects on cellular and chemical parameters, optimizing collection tube selection. Blood collection tube anticoagulant choice significantly affects test results. Your research would evaluate anticoagulant effects on different analytes, assess specimen quality across collection methods, examine stability differences, and establish optimal tube selection for different tests. The research prevents erroneous results from inappropriate specimen handling.

Topic 23: Prevalence and Clinical Significance of Abnormal Hemoglobin Variants in Sickle Cell Disease Screening Programs

This research identifies hemoglobinopathy patterns, contributes to comprehensive screening protocols, and informs genetic counseling practices. Hemoglobinopathy screening identifies individuals with sickle cell disease and trait enabling appropriate counseling and management. Your study would determine hemoglobinopathy prevalence in your population, assess screening test performance, examine clinical significance of different variants, and recommend comprehensive screening protocols. The research supports sickle cell disease prevention and management.

Topic 24: Evaluation of Bone Marrow Aspiration and Biopsy Procedures in Diagnosing Hematologic Malignancies and Bone Marrow Disorders

This study assesses diagnostic yield, technical complications, and pathologist interpretation consistency in malignancy identification. Bone marrow examination provides definitive diagnosis for many hematologic conditions. Your research would evaluate procedure complications, assess diagnostic yield across different conditions, examine interpretation consistency among pathologists, and determine optimal sampling techniques. The research improves hematologic malignancy diagnosis.

Topic 25: Assessment of Automated Coagulation Analyzer Performance in Monitoring Warfarin Therapy Effectiveness and Safety

This research examines INR accuracy, reagent reliability, and clinical decision-making impact, evaluating anticoagulation monitoring protocols. Accurate INR measurement ensures appropriate warfarin dosing preventing thrombotic and hemorrhagic complications. Your study would evaluate analyzer performance characteristics, assess INR accuracy and precision, examine reagent variation effects, and recommend quality assurance protocols. The research supports optimal anticoagulation management.

Clinical Chemistry and Metabolic Testing

Clinical chemistry topics address blood chemistry analysis, metabolic parameters, organ function testing, and electrolyte assessment. These fundamental diagnostic areas encompass essential tests in patient evaluation and disease monitoring across all medical specialties.

Topic 26: Impact of Fasting Status and Sample Collection Timing on Blood Chemistry Test Results Reliability in Routine Clinical Laboratory Operations

This study quantifies how pre-analytical variables affect metabolic parameters, establishing optimal specimen collection protocols for diagnostic accuracy. Fasting status and circadian variations affect many laboratory parameters. Your research would measure parameter variation with different fasting durations, assess collection timing effects, identify critical pre-analytical variables, and establish standardized specimen collection protocols. The research improves test result reliability and interpretation accuracy.

Topic 27: Evaluation of Electrolyte Analyzer Accuracy in Monitoring Critically Ill Patients in Intensive Care Unit Settings

This research assesses continuous monitoring devices in critical care, examining rapid result reporting impact on clinical interventions and patient outcomes. Critically ill patients require rapid electrolyte assessment enabling timely therapeutic interventions. Your study would evaluate analyzer accuracy and precision, assess clinical decision-making impact, examine turnaround time benefits, and recommend optimal monitoring protocols. The research improves critical care electrolyte management.

Topic 28: Assessment of Renal Function Testing Protocols in Detecting Drug-Induced Nephrotoxicity Among Patients on Long-Term Antiretroviral Therapy

This study monitors creatinine and electrolytes in HIV patients, identifying early kidney damage and preventing therapy-related complications. Antiretroviral medications can cause renal toxicity requiring early detection. Your research would monitor renal function parameters in treated patients, establish nephrotoxicity detection protocols, assess early intervention effectiveness, and recommend monitoring intervals. The research supports safe antiretroviral therapy.

Topic 29: Comparative Effectiveness of Different Lipid Profile Testing Methods in Cardiovascular Risk Assessment and Lipid Management Programs

This research compares direct and enzymatic assay methods, evaluating accuracy in guiding statin therapy and lifestyle intervention decisions. Lipid profile accuracy significantly impacts cardiovascular disease prevention decisions. Your study would compare different testing methodologies, assess accuracy in lipid measurement, evaluate cost-effectiveness, and examine impact on treatment decisions. The research improves cardiovascular risk assessment and management.

Topic 30: Development of Quality Assurance Procedures for Thyroid Function Testing in Screening and Monitoring Thyroid Disorders

This study establishes TSH and free T4 testing standards, ensuring reliable results for hypothyroidism and hyperthyroidism diagnosis and management. Thyroid testing accuracy is critical for appropriate diagnosis and therapy monitoring. Your research would develop comprehensive quality assurance procedures, establish reference ranges, assess test accuracy and precision, and implement monitoring protocols. The research ensures reliable thyroid function testing.

Conclusion and Professional Research Support

These 30 final year project topics for medical laboratory science students represent the cutting edge of diagnostic innovation, quality assurance, and clinical laboratory practice in 2026. Each topic offers meaningful research opportunities that bridge the gap between theoretical knowledge and practical laboratory application. The topics span critical areas including diagnostic techniques, laboratory standardization, biomarker discovery, molecular testing innovations, and clinical pathology applications—all essential domains for advancing diagnostic medicine.

Choosing from this comprehensive list of final year project topics ensures your research addresses contemporary challenges facing medical laboratories, particularly in resource-limited healthcare settings across Africa and beyond. Your project has the potential to improve diagnostic practices, contribute to patient safety, and establish you as a thoughtful healthcare professional committed to laboratory excellence.

The success of your final year project depends not only on selecting the right topic but also on accessing quality research materials, data analysis support, and expert guidance throughout your investigation. This is where professional research support can make a significant difference in your academic journey. Rather than struggling through the research process alone, consider partnering with experienced professionals who understand medical laboratory science research requirements and contemporary diagnostic trends.

For related topics and additional guidance on research writing, you may find value in exploring resources on writing comprehensive research chapters or reviewing additional seminar topics on microbiology for complementary perspective on laboratory science research.

Ready to transform your chosen topic into a comprehensive, professionally researched project? Contact Premium Researchers today via WhatsApp at https://wa.me/2348132546417 or email [email protected]. Our team of Master’s and PhD holders in medical laboratory science and related disciplines will provide complete project materials including literature reviews, methodology sections, data analysis, and professional formatting—all plagiarism-free and ready for submission.

Your success in completing an excellent final year project is our priority. Let Premium Researchers be your trusted academic partner in achieving your medical laboratory science degree.

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